Improvement of hepatocyte engraftment by co‐transplantation with pancreatic islets in hepatocyte transplantation
نویسندگان
چکیده
منابع مشابه
Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation.
Engraftment of donor hepatocytes is a critical step that determines the success of hepatocyte transplantation. Rapid and efficient integration of donor cells would enable prompt liver repopulation of these cells in response to selective proliferative stimuli offered by a preparative regimen. We have earlier demonstrated that hepatic irradiation (HIR) in combination with a variety of hepatotroph...
متن کاملHepatocyte Transplantation
Orthotopic liver transplantation is an established treatment for patients with severe acute and end-stage chronic liver disease. The shortage of donor organs continues to be the rate-limiting factor for liver transplantation throughout the world. Hepatocyte transplantation is a promising treatment for several liver diseases and can, also, be used as a ‘bridge’ to liver transplantation in cases ...
متن کاملHepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
OBJECTIVE Adenoviral delivery of hepatocyte growth factor (HGF) to rodent islets improves islet graft survival and function, markedly reducing the number of islets required to achieve glucose control. Here, we asked whether these prior observations in rodent models extend to nonhuman primate (NHP) islets. RESEARCH DESIGN AND METHODS NHP islets were transduced with murine (Ad.mHGF) or human (A...
متن کاملHepatocyte-like cells in the pancreatic islets: study of the human foetal pancreas and experimental models.
OBJECTIVE To determine the existence of hepatocyte-like cells in the human foetal pancreas. STUDY DESIGN Foetal pancreas was examined in parallel with two experimental models involving pancreatic tissue regeneration. Foetal pancreases (n = 20; 10 to 18 weeks) were obtained from spontaneous abortions and were histologically examined using haematoxylin-eosin and PAS staining. Tissues from food-...
متن کاملThromboinflammation in a Model of Hepatocyte Transplantation
Gustafson, E. 2016. Thromboinflammation. in a Model of Hepatocyte Transplantation. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 123. 75 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9592-3. Hepatocyte transplantation is an attractive method for the treatment of metabolic liver disease and acute liver failure. The clinical application of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Tissue Engineering and Regenerative Medicine
سال: 2021
ISSN: 1932-6254,1932-7005
DOI: 10.1002/term.3170